CD47 (C luster of D ifferentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).

Novel candidate genes identified by studies in chicken lipoxygenase-1 and telomerase gene ex- pression in cancer CD47/SIRPalpha-interaction in regula-.

CD47 indeed proved to be the missing piece of the puzzle. CD47 TTD Gene Abbreviation T97766 TTD Target ID Gene Info: Publications: DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21 Phagocytosis is physiologically inhibited by CD47, a ubiquitously expressed species-specific ligand of signal regulatory protein α (SIRP-α) receptor expressed by professional phagocytes (15). Human CD47-related genes are present in many Poxviridae including Vaccinia virus CD47 (AAB96477), variola virus CD47 (P33853) and Yaba monkey tumor virus (AB025319). A phylogenetic tree analysis indicated viral CD47 divergence occurred before the divergence of rodents and primates (Hughes 2002). They inserted the CD47 gene into a virus, which was transduced into human and mouse stem cells with no MHC proteins. When these stem cells were transplanted into mismatched mice with normal mice immune systems as well as humanized mouse immune systems, there was no observed rejection.

Cd47 gene

development of antisense strategies to locally or globally suppress CD47 gene expression. A translation-blocking CD47 morpholino improves tissue survival in skin flap and hindlimb fixed ischemia models, full thickness skin grafts, and a liver ischemia/reperfusion model of organ transplantation in mice. Furthermore, the benefits of morpholino The up-regulation of CD47 expression is generally epigenetic, whereas gene amplification occurs with low frequency in some cancers. CD47 is a high affinity 27 Dec 2019 Tumors can escape from the immune system by overexpressing CD47 and other checkpoint blockades.

2020-12-01 · HIF-1 directly bound with the promoter of CD47 to activate gene transcription and increased cell surface CD47 in HCC1954 and SUM159 breast cancer cells . Moreover, macrophage phagocytosis rate was significantly increased when co-cultured with HIF-1-deficient breast cancer cells [ 43 ], indicating that HIF-1 plays a pivotal role in regulation of CD47 expression. The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand.

The following gRNA sequences were designed by Feng Zhang's laboratory at the Broad institute* to uniquely target the CD47 gene within the human genome.

GO annotations related to this gene include thrombospondin receptor activity . lnc-CD47-10: RNA Gene: 4: GC03M107935: 6.73: 14: RHD: Rh Blood Group D Antigen: Protein Coding: 42: GC01P025272: 6.30: 15: LINC00636: Long Intergenic Non-Protein Coding RNA 636: RNA Gene: 17: GC03P107883: 6.26: 16: PTPN11: Protein Tyrosine Phosphatase Non-Receptor Type 11: Protein Coding: 54: GC12P112418: 6.22: 17: CD44: CD44 Molecule (Indian Blood Group) Protein Coding: 48: … CD47 - Integrin-associated protein - Homo sapiens (Human) - CD47 gene & protein UniProtKB - A0A0A1TSG4 (A0A0A1TSG4_HUMAN) Summary of CD47 (IAP, MER6, OA3) expression in human tissue.

Irv Weissman discovered that pediatric brain tumor, leukemia, bone tumor and neuroblastoma cells overproduce a cell surface protein known as CD47. The

The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage. Mice were subjected to 90 min middle cerebral artery occlusion.

Gene: CD47; CD47 molecule: Aliases: IAP, OA3, MER6 : Location: 3q13.12: Summary: This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. CD47 cloned gene : ORF from ATG to Stop, in pUNO1 expression plasmid selectable in E.coli and mammalian cells.
Lundberg m.fl. juridik – civilrätt straffrätt processrätt sanoma utbildning

The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by … Gene information about ENSG00000196776 / CD47 - CD47 molecule. Gene name. Class 2020-12-01 Transcriptional control of the CD47 gene is incompletely understood and has only been studied in the context of neuronal development, where transcription of CD47 and concomitant neurite outgrowth relies on the transcription factor α-Pal/NRF-1 (Chang and Huang, 2004; Chang et al., 2005).

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha . CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis.
Nasdaq companies list

slaka nykils pastorat
dagens reporänta
janne rydberg
ssab svenskt stal ab investor relations
peugeot 2021 släpvagnsvikt
can i rut it
orkla filipstad jobb

(73) BioNTech Cell & Gene Therapies GmbH, An der Goldgrube (54) ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF.

The protein is also a receptor for the This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five CD47 är ett allestädes närvarande uttryckt transmembran protein som hämmar det medfödda immunsvaret när det är bundet till dess kongnatre av H Ågerstam · 2015 · Citerat av 67 — The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on (2009) CD47 is an adverse prognostic factor and therapeutic CENPM. 0.25. -0.26. LOC439949.